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Maximize Results Every Workout With Signature Pre-Workout

Maximize Results Every Workout With Signature Pre-Workout - Bodybuilding.com

Fuel your workouts to achieve optimal results with our supercharged pre-workout formula.


BBCOM Editors
January 6, 2025

What is Pre-Workout?

“Pre-workout” is a general term for a variety of supplements to help you have the best workout possible. There are hundreds if not thousands of brands and formulations on the market in the pre-workout category. 

Why Take Bodybuilding.com’s Signature Pre-Workout?

Signature Pre-Workout contains proven ingredients to help with muscle growth, energy production, muscular endurance, blood flow, mental focus, and hydration. The biggest reason to take Signature Pre-Workout over other pre-workouts is that it contains L-leucine, which has shown to greatly increase muscle mass, help with fat loss, and prevent muscular fatigue.[1] 


Let’s explore more ways Signature can fuel your workouts to maximize results. 

Muscle Growth

Signature contains 3000mg of leucine, which is the minimal threshold amount for your body to start synthesizing protein. Leucine is arguably the most important branched-chain amino acid (BCAA), because you lose more of it while exercising. This vital BCAA regulates muscle protein synthesis by activating the mTOR pathway, while also helping delay muscular fatigue and prevent muscle breakdown during long or intense training sessions. Lastly, leucine also increases skeletal muscle insulin-like growth factor 1, or IGF-1, to help with muscle repair and growth.[2] 

Energy Production

With 200mg of caffeine, which equates to a cup of coffee, Signature Pre-Workout  can also boost your aerobic and anaerobic performance with a scientifically proven dose of energy. This will help increase your muscular endurance and power output, while enhancing high-intensity interval training and resistance to fatigue.[3-6]


Muscular Endurance

To delay muscle fatigue during intense exercise, Signature contains 1,500mg of the amino acid beta alanine, specifically CarnoSyn®, a high-quality patented version of beta-alanine certified to be pure and safe for sports.[7] A published, self-funded study found that CarnoSyn® supplementation was shown to effectively increase muscle carnosine content in an elderly population, leading to improved exercise capacity for resistance and reduced muscular fatigue.[8] Other studies have shown that beta-alanine is safe, effective, and can increase lean body mass, number of repetitions performed, and overall training volume.[9] It has also been shown to lower perceived fatigue during high volume workouts.[10]

Signature also contains 1,000mg of taurine, which can help improve your muscular strength by reducing muscle fatigue from oxidative stress and lactic acidosis. Taurine also plays a beneficial role in your metabolism, glucose regulation, energy levels, anti-inflammatory modulation, and antioxidant actions.[11] A meta-analysis found that a 1-3 gram daily dose of taurine supplementation can improve VO2 max, time to exhaustion, anaerobic performance, peak power, muscle recovery, and decrease metabolic markers such as lactate, creatine kinase, and phosphorus.[12]

Blood Flow


With5,000mg of citrulline—an amino acid found primarily in watermelon, which promotes the synthesis and bioavailability of nitric oxide—Signature Pre-Workout can also help increase blood flow.[13] These elevated nitrogen levels increase vasodilation and blood flow to your muscles, leading to better athletic performance in high-intensity anaerobic exercises and less post-exercise muscle soreness.[14]

Mental Focus

Signature contains 250mg of Lion’s Mane mushroom, a culinary and medicinal mushroom with potential benefits for cognition,mood enhancement, and reducing symptoms of anxiety and depression.[15] Lion’s mane has gained recent popularity because several scientific studies have shown improvement of brain health and cognition with a daily lion’s mane supplement. In a double-blind placebo controlled human study of mild Alzheimer patients, lion’s mane helped both the patient’s biomarkers and ability to perform activities of daily living.[16] Other scientifically rigorous trials have also confirmed that lion’s mane helped individuals improve their cognition scores on various tests.[17-18]

Hydration

Last but not least, Signature Pre-Workout contains sodium, potassium, magnesium, and calcium  to help your hydration. Electrolytes are often overlooked as pre-workout ingredients, but even mild dehydration can impair athletic ability by reducing blood volume, muscular strength, body temperature regulation, as well as decreaseenergy, mental focus, and perceived exertion. Just another bonus to this already stacked pre-workout. 


Additionally, Taurine also helps with hydration by regulating fluid between cells, especially during high-intensity exercise, andpromotes the transport of electrolytes such as sodium, potassium, and calcium to support muscle contraction and nerve function.

Takeaway

Signature Pre-workout truly has it all. With just one serving, you get leucine to help build muscle, beta-alanine to delay muscular fatigue, citrulline for increased blood flow, as well as caffeine for energy, lion’s mane for focus, and electrolytes and taurine to stay hydrated. Our powerhouse pre-workout formula is for those seeking peak performance in strength, endurance, and muscle-building—all while looking lean, muscular, and pumped. 

References
  1. Pedroso, J. A., Zampieri, T. T., & Donato, J., Jr (2015). Reviewing the Effects of L-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis. Nutrients, 7(5), 3914–3937. https://doi.org/10.3390/nu7053914 
  2. Church, D. D., Schwarz, N. A., Spillane, M. B., McKinley-Barnard, S. K., Andre, T. L., Ramirez, A. J., & Willoughby, D. S. (2016). l-Leucine Increases Skeletal Muscle IGF-1 but Does Not Differentially Increase Akt/mTORC1 Signaling and Serum IGF-1 Compared to Ursolic Acid in Response to Resistance Exercise in Resistance-Trained Men. Journal of the American College of Nutrition, 35(7), 627–638. https://doi.org/10.1080/07315724.2015.1132019 
  3. Mielgo-Ayuso, J., Marques-Jiménez, D., Refoyo, I., Del Coso, J., León-Guereño, P., & Calleja-González, J. (2019). Effect of Caffeine Supplementation on Sports Performance Based on Differences Between Sexes: A Systematic Review. Nutrients, 11(10), 2313. https://doi.org/10.3390/nu11102313
  4. Franco-Alvarenga, P. E., Brietzke, C., Canestri, R., Goethel, M. F., Viana, B. F., & Pires, F. O. (2019). Caffeine Increased Muscle Endurance Performance Despite Reduced Cortical Activation and Unchanged Neuromuscular Efficiency and Corticomuscular Coherence. Nutrients, 11(10), 2471. https://doi.org/10.3390/nu11102471
  5. Forbes, S. C., Candow, D. G., Smith-Ryan, A. E., Hirsch, K. R., Roberts, M. D., VanDusseldorp, T. A., Stratton, M. T., Kaviani, M., & Little, J. P. (2020). Supplements and Nutritional Interventions to Augment High-Intensity Interval Training Physiological and Performance Adaptations-A Narrative Review. Nutrients, 12(2), 390. https://doi.org/10.3390/nu12020390
  6. Wilk, M., Filip, A., Krzysztofik, M., Gepfert, M., Zajac, A., & Del Coso, J. (2020). Acute Caffeine Intake Enhances Mean Power Output and Bar Velocity during the Bench Press Throw in Athletes Habituated to Caffeine. Nutrients, 12(2), 406. https://doi.org/10.3390/nu12020406 
  7. Hobson, R. M., Saunders, B., Ball, G., Harris, R. C., & Sale, C. (2012). Effects of β-alanine supplementation on exercise performance: a meta-analysis. Amino acids, 43(1), 25–37. https://doi.org/10.1007/s00726-011-1200-z 
  8. del Favero, S., Roschel, H., Solis, M. Y., Hayashi, A. P., Artioli, G. G., Otaduy, M. C., Benatti, F. B., Harris, R. C., Wise, J. A., Leite, C. C., Pereira, R. M., de Sá-Pinto, A. L., Lancha-Junior, A. H., & Gualano, B. (2012). Beta-alanine (Carnosyn™) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity. Amino acids, 43(1), 49–56. https://doi.org/10.1007/s00726-011-1190-x 
  9. Trexler, E. T., Smith-Ryan, A. E., Stout, J. R., Hoffman, J. R., Wilborn, C. D., Sale, C., Kreider, R. B., Jäger, R., Earnest, C. P., Bannock, L., Campbell, B., Kalman, D., Ziegenfuss, T. N., & Antonio, J. (2015). International society of sports nutrition position stand: Beta-Alanine. Journal of the International Society of Sports Nutrition, 12, 30. https://doi.org/10.1186/s12970-015-0090-y 
  10. Hoffman, J. R., Ratamess, N. A., Faigenbaum, A. D., Ross, R., Kang, J., Stout, J. R., & Wise, J. A. (2008). Short-duration beta-alanine supplementation increases training volume and reduces subjective feelings of fatigue in college football players. Nutrition research (New York, N.Y.), 28(1), 31–35. https://doi.org/10.1016/j.nutres.2007.11.004 
  11. Schaffer, S., & Kim, H. W. (2018). Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomolecules & therapeutics, 26(3), 225–241. https://doi.org/10.4062/biomolther.2017.251 
  12. Kurtz, J. A., VanDusseldorp, T. A., Doyle, J. A., & Otis, J. S. (2021). Taurine in sports and exercise. Journal of the International Society of Sports Nutrition, 18(1), 39. https://doi.org/10.1186/s12970-021-00438-0 
  13. Burton-Freeman, B., Freeman, M., Zhang, X., Sandhu, A., & Edirisinghe, I. (2021). Watermelon and L-Citrulline in Cardio-Metabolic Health: Review of the Evidence 2000-2020. Current atherosclerosis reports, 23(12), 81. https://doi.org/10.1007/s11883-021-00978-5 
  14. Pérez-Guisado, J., & Jakeman, P. M. (2010). Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. Journal of strength and conditioning research, 24(5), 1215–1222. https://doi.org/10.1519/JSC.0b013e3181cb28e0 
  15. Chong, P. S., Fung, M. L., Wong, K. H., & Lim, L. W. (2019). Therapeutic Potential of Hericium erinaceus for Depressive Disorder. International journal of molecular sciences, 21(1), 163. https://doi.org/10.3390/ijms21010163 
  16. Li, I. C., Chang, H. H., Lin, C. H., Chen, W. P., Lu, T. H., Lee, L. Y., Chen, Y. W., Chen, Y. P., Chen, C. C., & Lin, D. P. (2020). Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Frontiers in aging neuroscience, 12, 155. https://doi.org/10.3389/fnagi.2020.00155 
  17. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy research : PTR, 23 (3), 367–372. https://doi.org/10.1002/ptr.2634 
  18. Saitsu, Y., Nishide, A., Kikushima, K., Shimizu, K., & Ohnuki, K. (2019). Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomedical research (Tokyo, Japan), 40(4), 125–131. https://doi.org/10.2220/biomedres.40.125

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